Molecular Sciences Bldg 21, James Cook University,
Townsville, 4811, Queensland, Australia
Telephone: 61-7-4781 6265 Fax: 61-7-4781 6078
The first stage of an immune response is the inflammatory response where unspecific mechanisms confine and destroy invading pathogens. An efficient defence can only be achieved when inflammatory cells can be recruited fast and efficiently to the site of the invasion. This recruitment depends on the presence of adhesion molecules and chemokines and is regulated by pro-inflammatory cytokines. Over the last years we have been interested in the molecular mechanisms involved in regulating this inflammatory cell migration.
Specifically, our work is focused on the TNF-mediated maturation of dendritic cells and the secondary maturation-dependent migration of these cells. This aspect of immunity is studied in the experimental model of a parasitic infection, the murine cutaneous leishmaniasis.
A second project is the analysis of B cell migration to the follicles of spleen and lymph node that is regulated by different TNF and LT-induced chemokines in gene deficient mouse strains.
These projects investigate the interaction of pro-inflammatory
cytokines and local mediators on a cellular level. They are designed to
deepen our understanding of the mechanisms that regulate efficient cell
migration of inflammatory cells from the periphery to the site of
inflammation and back to the secondary lymphoid organs.
Students interested in undertaking a PhD or Masters project in the Cellular Immunology Group should contact Heinrich Körner to discuss projects of mutual interest. Most higher degrees students would be expected to eligible for a scholarship through the Australian Postgraduate Award (APA) scheme, the James Cook University Postgraduate Research Scholarship or an equivalent national or international scholarship.
The Australian Postgraduate Award (APA) and James Cook University
Research Scholarship (JCUPRS) are open to applicants with, or who
to hold, a first class honours degree or equivalent by the end of the
and who wish to undertake full-time research Masters or PhD program. In
2003 the stipends for an APA were $18,006 pa (full time) or $9620
APA applicants must be Australian citizens or have been granted
resident status and lived in Australia continuously for 12 months prior
to 31 October 2001; Information and application forms can be obtained
the Research Scholarships Officer, or from the following website:
Closing Date: 31 October of each year
Students who have completed their undergraduate training in a BSc, BBiomedSc, BMedlabSc or equivalent program and are interested in participating in the Biochemistry and Molecular Biology Honours Program are encouraged to contact Heinrich Körner for a description of currently available projects. Honours studies require a full-time commitment for one year (two semesters) and can start in either February or August.
There are two main opportunities for undergraduates to participate in the ongoing research of the Cellular Immunology Group.
Students enrolled in BC3203 (Special Topics in Biochemistry and Molecular Biology - second semester) could ask that they undertake their research project in the Cellular Immunology Laboratory. Research projects will be in the area of molecular biology, cellular immunology.
Students can apply for a Comparative Genomics Centre Vacation
Award. The successful applicants receive instruction in the latest
DNA and cellular immunology techniques, receiving a stipend of $200 per
week for a full-time commitment of between 6 and 10 weeks over the
break. Applications for the 2004 CGC Vacation Studentships will be
later in the year and will close in late October. Contact Heinrich
for further details.