COMPARATIVE GENOMICS CENTRE

ANNUAL REPORT 2004 - 2005

Comparative Genomics Centre,
Molecular Sciences Bldg 21, James Cook University,
Townsville, 4811, Queensland, Australia
Telephone: 61-7-4781 6265 Fax:  61-7-4781 6078



The Comparative Genomics Centre (CGC) is a medical research centre founded in April 2003 by the School of Pharmacy and Molecular Sciences in association with the School of Medicine, at the James Cook University (JCU). After its second year of operation, the CGC accommodates 24 postgraduate students (up by eight from the previous year), six postdoctoral fellows and six research assistants. Over the last twelve months, the CGC has had 38 scientific manuscripts published or accepted for publication. It has an annual peer reviewed grant income in excess of $1.5 M  (up from $1.2 M in the previous year) from grants awarded by the National Health and Medical Research Council (NHMRC), the Australian Research Council, the March of Dimes Foundation (USA), Queensland Cancer Fund, the Alzheimer's Research Initiative, MS Society, Australian Academy of Sciences, Transtech Pharma, Eurochem, Alteon and the JCU intramural funding scheme.

Of particular note is the success achieved by the newest recruit to the Centre, Dr Heinrich Körner, who in his first year of competition in the national medical research grant round, was awarded grants totalling over a third of a million dollars. Dr Körner has expertise in the generation of targeted mutant (e.g. gene knockout) mice and was actually responsible for introducing this technology to Australia in the 1990's. His studies of inflammation in infection and models of other common diseases are likely to have a great impact, both locally and internationally.

The overall aim of the Centre is to use a variety of genetic models, including staghorn coral, fruit fly and mice, to study human disease from an evolutionary perspective. Disorders studied include birth defects, cancer, dementia, infectious diseases and autoimmunity. Housed in state-of-the-art custom built laboratories, the CGC offers a unique opportunity to research comparative genomics, molecular genetics, immunogenetics and immunology in a beautiful tropical environment adjacent to the Great Barrier Reef.

The CGC houses six research groups, each of which studies novel aspects of human health and disease. The Medical Genomics Group is working to determine the causes of autoimmune diseases using both cellular and genetic techniques. Current projects study: the genetics of autoimmune diabetes, gastritis and lupus in mice; the effects of mycobacteria on autoimmune diseases; and the role of immunoregulatory NKT cells in childhood diabetes. The Coral Genomics Group is studying a local Acropora  (staghorn coral) as a model system, in order to investigate issues central to the evolution of developmental mechanisms. The Drosophila Genetics Group's main focus is to investigate human disease using the model organism Drosophila melanogaster (fruit fly). As Drosophila share many key genes regulating cell division in man, they can provide important insights into disorders of chromosome segregation and cell cycle regulation. The Sociogenomics Group studies social insects, such as bees, ants and wasps, to model the genetics of social behaviours like altruism. The Neurobiology Group studies cell-based models of dementia and central nervous system inflammation, in order to identify compounds that can halt the progress of these diseases. The Cellular Immunology Group studies infections and inflammatory diseases in mice bearing targeted deletions of key immunological genes, in order to dissect the critical pathways involved in the initiation and resolution of immune responses.


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Medical Genomics Research Group, Autoimmunity Research Group, Comparative Genomics Centre,  Key words: Autoimmune diabetes, gene, genome, allele, locus, inherited, disease, Type 1 diabetes mellitus, childhood diabetes, lupus, systemic lupus erythematosus, hemolytic anaemia, hemolytic anemia, Coombs' test, antinuclear antibodies, renal failure, glomerulonephritis, gastritis, type A gastritis, pernicious anemia, immunology, popular science, biology.